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KMID : 0603820170230040380
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Journal of Experimental & Biomedical Science
2017 Volume.23 No. 4 p.380 ~ p.387
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Antioxidant Effects of Berchemia berchemiaefolia in Nerve Pain Models
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Lee Gil-Hyun
Hyun Kyung-Yae
Choi Seok-Cheol
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Abstract
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Berchemia berchemiaefolia (BB) are climbing plants or small to medium-sized trees that live in Africa, Asia and America. We performed the present study to investigate whether oral administration of Berchemia berchemiaefolia extract (BBE) protects SD rats from pain. The SD rat experimental groups were divided into four groups. Two of the animal model groups were fed on BBE (200 mg/kg or 100 mg/kg). We performed oral acute toxicity test to determine the optimal oral dose of BBE. To explore if BBE alleviated pain in the SD rat, we undertook the tail flick latency test and formalin test. Additionally, we conducted the anti-oxidative test. The findings of the present study suggest that Berchemia berchemiaefolia extract exhibits strong antioxidant and analgesic activities.
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KEYWORD
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Nociceptive action, Berchemia berchemiaefolia, Rat, Nerve pain, Tail flick latency test
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